We undertake and sponsor multidisciplinary and collaborative research projects aimed at improving the quality of life for childhood cancer survivors. Our main area of interest is reproduction - it is well known that chemo- and radiotherapies adversely affect reproductive capabilities, our aim is to quantify and mitigate these effects.
We describe how modern computational analysis of datasets provides important new insights into ovarian function and has generated hypotheses that are testable in the laboratory. Specifically, we can hypothesize that age is the most important factor for variations in individual ovarian non-growing follicle (NGF) populations, that anti-Müllerian hormone (AMH) levels generally rise and fall in childhood years before peaking in the mid-twenties, and that there are strong correlations between AMH levels and both NGF populations and rates of recruitment towards maturation, for age ranges before and after peak AMH levels. The full paper can be downloaded from Molecular Human Reproduction.