We undertake and sponsor multidisciplinary and collaborative research projects aimed at improving the quality of life for childhood cancer survivors. Our main area of interest is reproduction - it is well known that chemo- and radiotherapies adversely affect reproductive capabilities, our aim is to quantify and mitigate these effects.
The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and is under investigation as a screening tool for ovarian cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n = 59,994) we have generated and robustly validated the first model of ovarian volume from conception to 82 years of age. The full paper can be downloaded from PLoS ONE.